Product name:CIPROFLOXACIN
Company name:
DIN:01481515
Status:Marketed
Status date:2010-02-16
| Active ingredient(s) | Strength |
|---|---|
| FLOXACIN (CIPROFLOXACIN) | 500 MG |
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For consumers| Resource | Description |
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The Product Monograph is a scientific document that describes the properties, claims, indications and conditions of use of the product and contains any other information that may be required for optimal, safe and effective use. The Product Monograph includes three sections:
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Side effects are troublesome symptoms or feelings that you may not expect that show up when you are taking a medicine. All suspected side effects should be reported, especially those that are:
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Section C.01.020.1 of the Food and Drug Regulations and section 62 of the Medical Devices Regulations, require hospitals to report to Health Canada all serious adverse drug reactions (ADRs) and medical device incidents (MDIs) within 30 days of being documented within the hospital. This regulatory requirement only applies to hospitals. |
| After Health Canada completes the regulatory review process for a product, the clinical information included in a submission is made publicly available for non-commercial purposes. |
The main aim of this study was to evaluate the effect of different doses of the ciprofloxacin on the effect of ciprofloxacin on in vitro and in vivo experimental infection of human skin. The data were evaluated using the bioequivalence of the three main drug classes. After the first week of treatment with the antibiotic, a significant difference in the bioequivalence of the antibiotic with respect to ciprofloxacin was observed. The bioequivalence of the antibiotic with respect to ciprofloxacin was also evaluated. After the next week of the treatment with the antibiotic, a slight increase in the bioequivalence of the antibiotic with respect to ciprofloxacin was observed. The data obtained with the three drug classes are also presented in a graph (Fig.. ).
In vitro and in vivo infection assays revealed that the drug concentrations required to cause an inhibitory effect on the growth of the human skin model and the effect of ciprofloxacin were significantly lower than the antibiotic concentrations.
In the in vivo study of the treatment of patients with the infection of skin caused by Ciprofloxacin-resistant bacteria, a statistically significant difference was observed in the in vitro and in vivo infection assays. The results obtained in the in vivo experiment were also in line with the results obtained in the in vitro experiment. The results obtained in the in vitro experiment were also in line with the results obtained in the in vivo experiment.
The results of the in vitro experiment indicated that the antibiotic concentrations used in the study were much higher than in the in vivo experiment.
The present study showed that, in the human skin, the antibiotic concentration required to cause an inhibitory effect on the growth of the human skin model and the effect of ciprofloxacin were significantly lower than the antibiotic concentrations.
Citation:Rothmann G, Huxman J, Boon S, Cuker J, et al. (2020) Bioequivalence of three Ciprofloxacin-resistant strains of Streptococcus pneumoniae and Moraxella catarrhalis in the human skin. PLoS ONE 14(7): e96686. https://doi.org/10.1371/journal.pone.0096686
Editor:F. D. Lach, University of California, San Francisco, United States of America
Received:August 15, 2020;Accepted:November 6, 2020;Published:December 8, 2020
Copyright:© 2020 Rothmann G et al. This is an open access article distributed under the terms of the, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Data Availability:All relevant data are within the paper and its files.
Funding:The study was funded by the German Research Foundation (DFG) and the German Federal University of Technology (DFG-FU-DTC) (T-31, T-31-D-23). The funder was fully responsible for the design, conduct, and analysis of the study, and preparation of the manuscript.
Competing interests:The authors have declared that no competing interests exist.
Infections caused by bacterial pathogens are a major cause of morbidity and mortality in humans. The World Health Organization (WHO) recommends the use of antibiotic therapy to treat the infection in patients with no or mild symptoms of infection. In this sense, the ciprofloxacin-resistant strains ofS. pneumoniaeandP. catarrhalishave not been included in the WHO-recommended treatment guidelines (, ). However, these strains ofhave been reported to cause infections of the skin and respiratory tract.
The ciprofloxacin-resistant strains ofare usually caused by a broad spectrum of the antibiotic ciprofloxacin.
Treatment may vary between hospitals.
For many hospitals, the most common treatment is antibiotics.
For example, antibiotics may be prescribed to treat urinary tract infections (UTIs) and a variety of conditions such as bacterial vaginosis (bw). Others may be prescribed for respiratory tract infections and other UTI types.
Examples of antibiotics that may be prescribed for UTI treatment include:
Examples of antibiotics that may be prescribed for respiratory tract infections include:
In certain circumstances, your health care provider may suggest a switch to a different antibiotic.
Taking antibiotics is generally the safest and most effective way to treat UTIs, but it's important to follow the instructions provided by your health care provider.
The following are general guidelines for taking antibiotics. Please consult a doctor or nurse practitioner for specific guidance.
Antibiotic prescription: This is an important step in your treatment and is usually part of the initial antibiotic regimen. Your doctor may prescribe antibiotic medications or may order tests to determine the right antibiotic to use.
Antibiotic overuse: Overuse of antibiotics can lead to resistance and can increase the risk of antibiotic resistance. Examples of overuse antibiotics include:
It is recommended to take these precautions for at least four weeks before taking antibiotics to avoid antibiotic resistance. Some antibiotics can cause serious problems, such as diarrhea, which can be life-threatening. To avoid antibiotic resistance, your health care provider may advise you to take a short course of antibiotics, and wait for the full course of antibiotics to clear.
Common side effects of antibiotics may include:
If you experience side effects, contact your health care provider or pharmacist right away.
Antibiotic use during pregnancy: As an unborn baby, it may harm the developing baby. The most common way to prevent it is to use a reliable and effective birth control method, such as a condom or diaphragm. If this is not possible or if your pregnancy requires additional care, your health care provider may suggest a pregnancy test that can be used to prevent pregnancy.
During pregnancy, it is also important to talk to your health care provider about taking antibiotics while you're pregnant. Some antibiotics may increase the risk of a miscarriage or the risk of a possible baby’s brain injury.
Antibiotic resistance: If you experience persistent diarrhea after taking antibiotics, it may be hard to get a full antibiotic prescription.
Antibiotic resistance is a serious problem. If you're experiencing resistance to an antibiotic or have a history of bacterial infections that may be resistant to other antibiotics, your health care provider may suggest antibiotic therapy. If you have a history of antibiotic resistance, your health care provider may recommend switching to another antibiotic that is effective in treating the same infection. Some antibiotics may cause side effects such as nausea, vomiting, diarrhea, or skin rash.
Antibiotic antibiotics can lead to bacterial infections. Antibiotics used to treat UTIs, such as amoxicillin and ciprofloxacin, can make it harder to treat UTIs caused by bacteria. This can make the bacteria more resistant to other antibiotics. This is why antibiotics are so important in treating UTIs.
Brand Name: Cipro, brand name for ciprofloxacin. It belongs to the fluoroquinolone class of antibiotics known as fluoroquinolones.
This medicine is also called.
Common Uses
Dose form:250 mg
Form: Tablet
Dosage
This medicine is usually given twice a day for 7 to 14 days. Do not exceed the daily dose.
Side Effects
In some people, symptoms of an allergic reaction may be mild to severe. These are usually mild to moderate and should improve on their own. In case of severe side effects like allergic reactions, you should seek medical advice.
Storage
Store this medicine in a cool, dry place, away from direct sunlight. Do not store it in the bathroom.
Ciprofloxacin (ciprofloxacin generic name) is a synthetic version of ciprofloxacin. It is a fluoroquinolone antibacterial agent.How to use Ciprofloxacin
The recommended dosage of Ciprofloxacin is one 500 mg tablet once a day for 7 to 14 days. The maximum daily dose should not exceed 250 mg, taken as an oral suspension.
Take this medicine by mouth with or without food as directed by your doctor, usually every 8 hours, or every 30 minutes to treat the infection. Take it with or without food as directed by your doctor, usually once a day. Do not take Ciprofloxacin more often than once a day.
In case of severe side effects, you should consult your doctor or pharmacist. They can advise you on the most appropriate course of treatment.
Drug Interactions
Ciprofloxacin should not be used together with other antibacterial drugs. In case of a drug interaction, your doctor or pharmacist should be consulted. Do not use Ciprofloxacin together or combine it with other drugs, especially:
Do not share Ciprofloxacin with anyone else.
Missed Dose
If you miss a dose of Ciprofloxacin, take it as soon as possible. If it is almost time for your next dose, skip the missed dose and return to your regular dosing schedule. Do not take 2 doses at once.
Store Ciprofloxacin at room temperature away from moisture, heat, and light.
Ciprofloxacin is an antibiotic, which means that it does not kill bacteria. It is used to treat infections of the urinary tract, skin and soft tissue. Ciprofloxacin does not cure any other infections. However, it can be used to treat certain other conditions, so consult your doctor if you are unsure about your treatment.Ciprofloxacin (Ciprofloxacin Tablets) is an antibiotic used to treat a wide range of infections, including urinary tract infections, bronchitis and infections of the skin and soft tissue. Ciprofloxacin (Ciprofloxacin Tablets) is a fluoroquinolone antibiotic that works by stopping the bacteria from growing and multiplying, allowing the body to fight off the infection completely.
Ciprofloxacin (Ciprofloxacin Tablets) is used to treat a wide range of infections, including urinary tract infections, bronchitis and infections of the skin and soft tissue. Ciprofloxacin (Ciprofloxacin Tablets) is also sometimes prescribed to treat infections caused by the organisms that cause pneumonia, gonorrhea, pneumonia and urinary tract infections. Ciprofloxacin (Ciprofloxacin Tablets) is also used to treat infections of the skin and soft tissue such as cellulitis, wound infections, abscesses and osteomyelitis.
Ciprofloxacin (Ciprofloxacin Tablets) is usually taken orally with a meal to help reduce the amount of stomach irritation caused by the medication. It should be taken at least 1 hour before food or dairy products, and should be taken only when needed. Ciprofloxacin (Ciprofloxacin Tablets) should not be used to treat a viral infection such as the common cold or flu.
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